Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI

Mechanistic understanding of complex clinical drug–drug interactions (DDIs) with potential involvement of multiple elimination pathways has been challenging, especially given the general lack of specific probe substrates for transporters. Here, we conducted a clinical DDI study to evaluate the inter...

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Detalles Bibliográficos
Autores principales: Jones, Nicholas S., Yoshida, Kenta, Salphati, Laurent, Kenny, Jane R., Durk, Matthew R., Chinn, Leslie W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977399/
https://www.ncbi.nlm.nih.gov/pubmed/31376152
http://dx.doi.org/10.1002/cpt.1599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977399/
https://www.ncbi.nlm.nih.gov/pubmed/31376152
http://dx.doi.org/10.1002/cpt.1599

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