Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

The high demand of the pharmaceutical industry for new modalities to address the diversification of biological targets with large surfaces of interaction led us to investigate the replacement of α-amino acid residues with ureido units at selected positions in peptides to improve potency and generate...

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Detalles Bibliográficos
Autores principales: Fremaux, Juliette, Venin, Claire, Mauran, Laura, Zimmer, Robert, Koensgen, Florian, Rognan, Didier, Bitsi, Stavroula, Lucey, Maria A., Jones, Ben, Tomas, Alejandra, Guichard, Gilles, Goudreau, Sébastien R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977461/
https://www.ncbi.nlm.nih.gov/pubmed/32015811
http://dx.doi.org/10.1039/c9sc02079a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977461/
https://www.ncbi.nlm.nih.gov/pubmed/32015811
http://dx.doi.org/10.1039/c9sc02079a

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