Cargando…

Ubenimex induces autophagy inhibition and EMT suppression to overcome cisplatin resistance in GC cells by perturbing the CD13/EMP3/PI3K/AKT/NF-κB axis

Cisplatin (CDDP)-based chemotherapy is a standard treatment for gastric cancer (GC). However, chemoresistance is a major obstacle for CDDP application. Exploring underlying mechanisms of CDDP resistance development in GC and selecting an effective strategy to overcome CDDP resistance remain a challe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Qie, Jing, Fan-Jing, Xu, Wen, Li, Xiao, Li, Xin, Sun, Jia-Lin, Xing, Xiao-Min, Zhou, Chang-Kai, Jing, Fan-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977684/ https://www.ncbi.nlm.nih.gov/pubmed/31895687 http://dx.doi.org/10.18632/aging.102598

Ejemplares similares

CD13 downregulation mediated by ubenimex inhibits autophagy to overcome 5-FU resistance by disturbing the EMP3/FAK/NF-κB pathway in gastric cancer cells
por: Xiu, Ting, et al.
Publicado: (2022)

Ubenimex suppresses glycolysis mediated by CD13/Hedgehog signaling to enhance the effect of cisplatin in liver cancer
por: Shi, Yunyan, et al.
Publicado: (2023)

Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins
por: Guo, Qie, et al.
Publicado: (2019)

Ubenimex suppresses Pim-3 kinase expression by targeting CD13 to reverse MDR in HCC cells
por: Guo, Qie, et al.
Publicado: (2017)

SLC6A14 Depletion Contributes to Amino Acid Starvation to Suppress EMT-Induced Metastasis in Gastric Cancer by Perturbing the PI3K/AKT/mTORC1 Pathway
por: Guo, Qie, et al.
Publicado: (2022)

Ubenimex Suppresses the Ability of Migration and Invasion in Gastric Cancer Cells by Alleviating the Activity of the CD13/NAB1/MAPK Pathway
por: Liu, Xuehui, et al.
Publicado: (2021)

Expression of EMP1, EMP2, and EMP3 in breast phyllodes tumors
por: Cha, Yoon Jin, et al.
Publicado: (2020)

EMP3 mediates glioblastoma‐associated macrophage infiltration to drive T cell exclusion
por: Chen, Qun, et al.
Publicado: (2021)

MicroRNA-95-3p serves as a contributor to cisplatin resistance in human gastric cancer cells by targeting EMP1/PI3K/AKT signaling
por: Ni, Qingfeng, et al.
Publicado: (2021)

Inhibition of Tumor Cell Invasion by Ubenimex (Bestatin) in vitro
por: Saiki, Ikuo, et al.
Publicado: (1989)

14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling
por: Luo, Jing, et al.
Publicado: (2018)

Role of ubenimex as an anticancer drug and its synergistic effect with Akt inhibitor in human A375 and A2058 cells
por: Wang, Xiaoqing, et al.
Publicado: (2018)

Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism
por: Liu, Shuai, et al.
Publicado: (2016)

Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells
por: Han, Liping, et al.
Publicado: (2017)

Sirt6 mRNA-incorporated endothelial microparticles (EMPs) attenuates DM patient-derived EMP-induced endothelial dysfunction
por: Jing, Tong, et al.
Publicado: (2017)

Ubenimex, an APN inhibitor, could serve as an anti-tumor drug in RT112 and 5637 cells by operating in an Akt-associated manner
por: Wang, Xiaoqing, et al.
Publicado: (2018)

Overcoming EMT-driven therapeutic resistance by BH3 mimetics
por: Keitel, Ulrike, et al.
Publicado: (2014)

Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways
por: Zhang, Weizhe, et al.
Publicado: (2018)

Targeting EMP3 suppresses proliferation and invasion of hepatocellular carcinoma cells through inactivation of PI3K/Akt pathway
por: Hsieh, Yi-Hsien, et al.
Publicado: (2015)

The simulation experiment of EMP coupling to typical digital devices
por: Li Xiao Wei, et al.
Publicado: (2002)

Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway
por: Wang, Yanjun, et al.
Publicado: (2019)

PD-L1 Expression Is Regulated By NF-κB During EMT Signaling In Gastric Carcinoma
por: Xu, Dan, et al.
Publicado: (2019)

EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations
por: Zhou, Wei, et al.
Publicado: (2009)

PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma
por: Gao, Yuan-Feng, et al.
Publicado: (2016)

MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis
por: Dian, Mei-Juan, et al.
Publicado: (2021)

Clinical efficacy of intravesical gemcitabine combined with ubenimex in patients with non-muscle-invasive bladder carcinoma after transurethral resection of bladder tumor
por: Shao, Li-jun, et al.
Publicado: (2022)

MicroRNA-654-3p enhances cisplatin sensitivity by targeting QPRT and inhibiting the PI3K/AKT signaling pathway in ovarian cancer cells
por: Niu, Yi-Chao, et al.
Publicado: (2020)

The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy
por: Liang, Fan, et al.
Publicado: (2019)

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429
por: Wang, Xiaofeng, et al.
Publicado: (2022)

Livin participates in resistance to trastuzumab therapy for breast cancer through ERK1/2 and AKT pathways and promotes EMT-like phenotype
por: Li, Fan, et al.
Publicado: (2018)

Identification of EMP1 as a critical gene for cisplatin resistance in ovarian cancer by using integrated bioinformatics analysis
por: Zeng, Qingsong, et al.
Publicado: (2023)

Ubenimex Combined with Pemetrexed Upregulates SOCS1 to Inhibit Lung Adenocarcinoma Progression via the JAK2-STAT3 Signaling Pathway
por: Chen, Quan, et al.
Publicado: (2022)

Ubenimex Activates the E‐Cadherin‐mediated Adhesion of a Breast Cancer Cell Line YMB‐S
por: Fujioka, Seiji, et al.
Publicado: (1995)

A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma
por: YAMASHITA, MASAFUMI, et al.
Publicado: (2016)

Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma
por: Wang, Y, et al.
Publicado: (2014)

Smad3 Sensitizes Hepatocelluar Carcinoma Cells to Cisplatin by Repressing Phosphorylation of AKT
por: Zhou, Hong-Hao, et al.
Publicado: (2016)

The ILEI/LIFR complex induces EMT via the Akt and ERK pathways in renal interstitial fibrosis
por: Zhou, Jieqing, et al.
Publicado: (2022)

Expression of EMP 1, 2, and 3 in Adrenal Cortical Neoplasm and Pheochromocytoma
por: Cha, Yoon Jin, et al.
Publicado: (2023)

Combined effects of EMP and RF field on emotional behavior in mice
por: Qin, Tongzhou, et al.
Publicado: (2023)

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer
por: Tsukamoto, Hirohisa, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_0g30m0lfrl84be05p2t20fnal6