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Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release
Multiple organ dysfunction induced by sepsis often involves kidney injury. Extracellular histones released in response to damage-associated molecular patterns are known to facilitate sepsis-induced organ dysfunction. Recombinant human soluble thrombomodulin (rhTM) and its lectin-like domain (D1) exe...
Autores principales: | Akatsuka, Masayuki, Masuda, Yoshiki, Tatsumi, Hiroomi, Yamakage, Michiaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977725/ https://www.ncbi.nlm.nih.gov/pubmed/31971961 http://dx.doi.org/10.1371/journal.pone.0228093 |
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