Inhibition of synucleinopathic seeding by rationally designed inhibitors

Seeding, in the context of amyloid disease, is the sequential transfer of pathogenic protein aggregates from cell-to-cell within affected tissues. The structure of pathogenic seeds provides the molecular basis and enables rapid conversion of soluble protein into fibrils. To date, there are no inhibi...

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Detalles Bibliográficos
Autores principales: Sangwan, Smriti, Sahay, Shruti, Murray, Kevin A, Morgan, Sophie, Guenther, Elizabeth L, Jiang, Lin, Williams, Christopher K, Vinters, Harry V, Goedert, Michel, Eisenberg, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977966/
https://www.ncbi.nlm.nih.gov/pubmed/31895037
http://dx.doi.org/10.7554/eLife.46775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977966/
https://www.ncbi.nlm.nih.gov/pubmed/31895037
http://dx.doi.org/10.7554/eLife.46775

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