Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome

The methyl-CpG-binding protein 2 gene, MECP2, is an X chromosome-linked gene encoding the MeCP2 protein, and mutations of MECP2 cause Rett syndrome (RTT). Previous study has shown that re-expression of SUMO-modified MeCP2 in Mecp2-null neurons rescues synaptic and behavioral deficits in Mecp2 condit...

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Detalles Bibliográficos
Autores principales: Hsu, Wei-Lun, Ma, Yun-Li, Liu, Yen-Chen, Tai, Derek J. C., Lee, Eminy H. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978308/
https://www.ncbi.nlm.nih.gov/pubmed/31974426
http://dx.doi.org/10.1038/s41598-020-57745-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978308/
https://www.ncbi.nlm.nih.gov/pubmed/31974426
http://dx.doi.org/10.1038/s41598-020-57745-w

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