Silencing E3 Ubiqutin ligase ITCH as a potential therapy to enhance chemotherapy efficacy in p53 mutant neuroblastoma cells

P53 mutations are responsible for drug-resistance of tumour cells which impacts on the efficacy of treatment. Alternative tumour suppressor pathways need to be explored to treat p53- deficient tumours. The E3 ubiquitin ligase, ITCH, negatively regulates the tumour suppressor protein TP73, providing...

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Detalles Bibliográficos
Autores principales: Meng, Jinhong, Tagalakis, Aristides D., Hart, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978385/
https://www.ncbi.nlm.nih.gov/pubmed/31974512
http://dx.doi.org/10.1038/s41598-020-57854-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978385/
https://www.ncbi.nlm.nih.gov/pubmed/31974512
http://dx.doi.org/10.1038/s41598-020-57854-6

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