Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides. Erastin, the ferroptosis activator, binds to voltage-dependent anion channels VDAC2 and VDCA3, but treatment with erastin can result in the degradation of the channel...

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Detalles Bibliográficos
Autores principales: Yang, Yongfei, Luo, Meiying, Zhang, Kexin, Zhang, Jun, Gao, Tongtong, Connell, Douglas O’, Yao, Fengping, Mu, Changwen, Cai, Bingyu, Shang, Yuxue, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978386/
https://www.ncbi.nlm.nih.gov/pubmed/31974380
http://dx.doi.org/10.1038/s41467-020-14324-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978386/
https://www.ncbi.nlm.nih.gov/pubmed/31974380
http://dx.doi.org/10.1038/s41467-020-14324-x

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