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p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids
In this study, we take advantage of human induced pluripotent stem (iPS) cell-derived neural stem cells and brain organoids to study the role of p53 during human brain development. We knocked down (KD) p53 in human neuroepithelial stem (NES) cells derived from iPS cells. Upon p53KD, NES cells rapidl...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978389/ https://www.ncbi.nlm.nih.gov/pubmed/31974372 http://dx.doi.org/10.1038/s41419-019-2208-7 |