Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease

While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer’s disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 regi...

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Autores principales: Chockanathan, Udaysankar, Warner, Emily J., Turpin, Loel, O’Banion, M. Kerry, Padmanabhan, Krishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978514/
https://www.ncbi.nlm.nih.gov/pubmed/31974405
http://dx.doi.org/10.1038/s41598-020-58038-y
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author Chockanathan, Udaysankar
Warner, Emily J.
Turpin, Loel
O’Banion, M. Kerry
Padmanabhan, Krishnan
author_facet Chockanathan, Udaysankar
Warner, Emily J.
Turpin, Loel
O’Banion, M. Kerry
Padmanabhan, Krishnan
author_sort Chockanathan, Udaysankar
collection PubMed
description While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer’s disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population’s coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation causes to the computations performed by neural circuits.
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spelling pubmed-69785142020-01-30 Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease Chockanathan, Udaysankar Warner, Emily J. Turpin, Loel O’Banion, M. Kerry Padmanabhan, Krishnan Sci Rep Article While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer’s disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population’s coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation causes to the computations performed by neural circuits. Nature Publishing Group UK 2020-01-23 /pmc/articles/PMC6978514/ /pubmed/31974405 http://dx.doi.org/10.1038/s41598-020-58038-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chockanathan, Udaysankar
Warner, Emily J.
Turpin, Loel
O’Banion, M. Kerry
Padmanabhan, Krishnan
Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
title Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
title_full Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
title_fullStr Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
title_full_unstemmed Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
title_short Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
title_sort altered dorsal ca1 neuronal population coding in the app/ps1 mouse model of alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978514/
https://www.ncbi.nlm.nih.gov/pubmed/31974405
http://dx.doi.org/10.1038/s41598-020-58038-y
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