Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate

Mutations in the gene encoding for dystrophin leads to structural and functional deterioration of cardiomyocytes and is a hallmark of cardiomyopathy in Duchenne muscular dystrophy (DMD) patients. Administration of recombinant adeno-associated viral vectors delivering microdystrophin or ribonucleotid...

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Detalles Bibliográficos
Autores principales: Kolwicz, Stephen C., Hall, John K., Moussavi-Harami, Farid, Chen, Xiolan, Hauschka, Stephen D., Chamberlain, Jeffrey S., Regnier, Michael, Odom, Guy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978556/
https://www.ncbi.nlm.nih.gov/pubmed/31998848
http://dx.doi.org/10.1016/j.jacbts.2019.06.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978556/
https://www.ncbi.nlm.nih.gov/pubmed/31998848
http://dx.doi.org/10.1016/j.jacbts.2019.06.006

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