Mitochondrial DNA Promotes NLRP3 Inflammasome Activation and Contributes to Endothelial Dysfunction and Inflammation in Type 1 Diabetes

Background: NLRP3 inflammasome activation in response to several signals, including mitochondrial DNA (mDNA), regulates inflammatory responses by caspase-1 activation and interleukin-1β (IL-1β) release. Circulating mDNA is linked to micro and macrovascular complications in diabetes. However, a role...

Descripción completa

Detalles Bibliográficos
Autores principales: Pereira, Camila A., Carlos, Daniela, Ferreira, Nathanne S., Silva, Josiane F., Zanotto, Camila Z., Zamboni, Dario S., Garcia, Valéria D., Ventura, Dora Fix, Silva, João S., Tostes, Rita C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978691/
https://www.ncbi.nlm.nih.gov/pubmed/32009974
http://dx.doi.org/10.3389/fphys.2019.01557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978691/
https://www.ncbi.nlm.nih.gov/pubmed/32009974
http://dx.doi.org/10.3389/fphys.2019.01557

Ejemplares similares