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Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function

As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid (GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride ion (Cl(−)) flow, which relies on the intracellular chloride concentration ([Cl(−)](i)) of the postsynaptic neuron. The Na-K-2C...

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Detalles Bibliográficos
Autores principales: Liu, Ru, Wang, Junling, Liang, Shuli, Zhang, Guojun, Yang, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978738/
https://www.ncbi.nlm.nih.gov/pubmed/32010056
http://dx.doi.org/10.3389/fneur.2019.01407