O(6)-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy

Chemoresistance has been a significant problem affecting the efficacy of drugs targeting tumors for decades. MGMT, known as O(6)-methylguanine-DNA methyltransferase, is a DNA repair enzyme that plays an important role in chemoresistance to alkylating agents. Hence, MGMT is considered a promising tar...

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Detalles Bibliográficos
Autores principales: Yu, Wei, Zhang, Lili, Wei, Qichun, Shao, Anwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979006/
https://www.ncbi.nlm.nih.gov/pubmed/32010632
http://dx.doi.org/10.3389/fonc.2019.01547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979006/
https://www.ncbi.nlm.nih.gov/pubmed/32010632
http://dx.doi.org/10.3389/fonc.2019.01547

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