Live vaccine consisting of attenuated Salmonella secreting and delivering Brucella ribosomal protein L7/L12 induces humoral and cellular immune responses and protects mice against virulent Brucella abortus 544 challenge

The present study employs the Brucella abortus L7/L12 antigen in a Salmonella secretion platform and investigates its ability to induce protective immune responses against wild type challenge in BALB/c mice. The highly conserved L7/L12 open reading frame was PCR amplified from B. abortus and cloned...

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Detalles Bibliográficos
Autores principales: Senevirathne, Amal, Hewawaduge, Chamith, Lee, John Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979349/
https://www.ncbi.nlm.nih.gov/pubmed/31973749
http://dx.doi.org/10.1186/s13567-020-0735-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979349/
https://www.ncbi.nlm.nih.gov/pubmed/31973749
http://dx.doi.org/10.1186/s13567-020-0735-y

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