Enantioselective carbene insertion into the N–H bond of benzophenone imine

Efficient enantioselective insertion of α-diazoesters into the N–H bond of N-sp(2)-hybridized benzophenone imine was realized by using Rh(2)(esp)(2) and chiral guanidine cooperative catalysis. Both aliphatic and aromatic substituted α-amino esters were obtained in high yields (up to 99%) and good en...

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Detalles Bibliográficos
Autores principales: Yang, Jian, Ruan, Peiran, Yang, Wei, Feng, Xiaoming, Liu, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979361/
https://www.ncbi.nlm.nih.gov/pubmed/32110317
http://dx.doi.org/10.1039/c9sc03354h
Descripción
Sumario:Efficient enantioselective insertion of α-diazoesters into the N–H bond of N-sp(2)-hybridized benzophenone imine was realized by using Rh(2)(esp)(2) and chiral guanidine cooperative catalysis. Both aliphatic and aromatic substituted α-amino esters were obtained in high yields (up to 99%) and good enantioselectivities (up to 95.5 : 4.5 er) under mild reaction conditions.

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