scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens

We present scMAGeCK, a computational framework to identify genomic elements associated with multiple expression-based phenotypes in CRISPR/Cas9 functional screening that uses single-cell RNA-seq as readout. scMAGeCK outperforms existing methods, identifies genes and enhancers with known and novel fu...

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Detalles Bibliográficos
Autores principales: Yang, Lin, Zhu, Yuqing, Yu, Hua, Cheng, Xiaolong, Chen, Sitong, Chu, Yulan, Huang, He, Zhang, Jin, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979386/
https://www.ncbi.nlm.nih.gov/pubmed/31980032
http://dx.doi.org/10.1186/s13059-020-1928-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979386/
https://www.ncbi.nlm.nih.gov/pubmed/31980032
http://dx.doi.org/10.1186/s13059-020-1928-4

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