Cargando…
Mycobacterial virulence: impact on immunogenicity and vaccine research
The borderline between virulence and efficacy in live attenuated vaccine strains is often blurred and this is also the case for the Bacillus Calmette–Guérin (BCG), the only currently licensed anti-tuberculosis vaccine used on a large, global scale, which was obtained almost 100 years ago. While BCG...
Autores principales: | Kroesen, Vera M., Madacki, Jan, Frigui, Wafa, Sayes, Fadel, Brosch, Roland |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979476/ https://www.ncbi.nlm.nih.gov/pubmed/32047597 http://dx.doi.org/10.12688/f1000research.20572.1 |
Ejemplares similares
-
ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains
por: Madacki, Jan, et al.
Publicado: (2021) -
Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential
por: Pérez, Irene, et al.
Publicado: (2020) -
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection
por: Ates, Louis S., et al.
Publicado: (2018) -
Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli
por: Malaga, Wladimir, et al.
Publicado: (2023) -
The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy
por: Pérez, Irene, et al.
Publicado: (2022)