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Enolization rates control mono- versus di-fluorination of 1,3-dicarbonyl derivatives
Fluorine-containing 1,3-dicarbonyl derivatives are essential building blocks for drug discovery and manufacture. To understand the factors that determine selectivity between mono- and di-fluorination of 1,3-dicarbonyl systems, we have performed kinetic studies of keto–enol tautomerism and fluorinati...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979503/ https://www.ncbi.nlm.nih.gov/pubmed/32110319 http://dx.doi.org/10.1039/c9sc04185k |