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Toxoplasma gondii Recruits Factor H and C4b-Binding Protein to Mediate Resistance to Serum Killing and Promote Parasite Persistence in vivo

Regulating complement is an important step in the establishment of infection by microbial pathogens. Toxoplasma gondii actively resists complement-mediated killing in non-immune human serum (NHS) by inactivating C3b, however the precise molecular basis is unknown. Here, a flow cytometry-based C3b bi...

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Detalles Bibliográficos
Autores principales: Sikorski, Patricia M., Commodaro, Alessandra G., Grigg, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979546/
https://www.ncbi.nlm.nih.gov/pubmed/32010145
http://dx.doi.org/10.3389/fimmu.2019.03105