Formal Synthesis of (±)-Allocolchicine Via Gold-Catalysed Direct Arylation: Implication of Aryl Iodine(III) Oxidant in Catalyst Deactivation Pathways

ABSTRACT: A concise formal synthesis of racemic allocolchicine has been developed, centred on three principal transformations: a retro-Brook alkylation reaction to generate an arylsilane, a gold-catalysed arylative cyclisation to generate the B-ring via biaryl linkage, and a palladium-catalysed carb...

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Detalles Bibliográficos
Autores principales: Corrie, Tom J. A., Lloyd-Jones, Guy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979697/
https://www.ncbi.nlm.nih.gov/pubmed/32025176
http://dx.doi.org/10.1007/s11244-017-0742-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979697/
https://www.ncbi.nlm.nih.gov/pubmed/32025176
http://dx.doi.org/10.1007/s11244-017-0742-z

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