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Formal Synthesis of (±)-Allocolchicine Via Gold-Catalysed Direct Arylation: Implication of Aryl Iodine(III) Oxidant in Catalyst Deactivation Pathways

ABSTRACT: A concise formal synthesis of racemic allocolchicine has been developed, centred on three principal transformations: a retro-Brook alkylation reaction to generate an arylsilane, a gold-catalysed arylative cyclisation to generate the B-ring via biaryl linkage, and a palladium-catalysed carb...

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Detalles Bibliográficos
Autores principales:	Corrie, Tom J. A., Lloyd-Jones, Guy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2017
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979697/ https://www.ncbi.nlm.nih.gov/pubmed/32025176 http://dx.doi.org/10.1007/s11244-017-0742-z

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