The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice

The immune checkpoint programmed cell death protein 1 (PD-1) plays a major role in T cell exhaustion in cancer and chronic HIV infection. The inhibitor of apoptosis protein antagonist Debio 1143 (D1143) enhances tumor cell death and synergizes with anti-PD-1 agents to promote tumor immunity and disp...

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Detalles Bibliográficos
Autores principales: Bobardt, Michael, Kuo, Joseph, Chatterji, Udayan, Wiedemann, Norbert, Vuagniaux, Gregoire, Gallay, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980394/
https://www.ncbi.nlm.nih.gov/pubmed/31978106
http://dx.doi.org/10.1371/journal.pone.0227715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980394/
https://www.ncbi.nlm.nih.gov/pubmed/31978106
http://dx.doi.org/10.1371/journal.pone.0227715

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