Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

BACKGROUND: There is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its pathogenesis. Understanding how perturbations in metabolism are related to AD is critical to identifying novel targets for disease-mo...

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Detalles Bibliográficos
Autores principales: Mahajan, Uma V., Varma, Vijay R., Griswold, Michael E., Blackshear, Chad T., An, Yang, Oommen, Anup M., Varma, Sudhir, Troncoso, Juan C., Pletnikova, Olga, O’Brien, Richard, Hohman, Timothy J., Legido-Quigley, Cristina, Thambisetty, Madhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980402/
https://www.ncbi.nlm.nih.gov/pubmed/31978055
http://dx.doi.org/10.1371/journal.pmed.1003012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980402/
https://www.ncbi.nlm.nih.gov/pubmed/31978055
http://dx.doi.org/10.1371/journal.pmed.1003012

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