Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey

Accumulation of lipofuscin bisretinoids in the retina contributes to pathogenesis of macular degeneration. Retinol-Binding Protein 4 (RBP4) antagonists reduce serum retinol concentrations thus partially reducing retinol delivery to the retina which decreases bisretinoid synthesis. BPN-14136 is a nov...

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Detalles Bibliográficos
Autores principales: Racz, Boglarka, Varadi, Andras, Pearson, Paul G., Petrukhin, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980506/
https://www.ncbi.nlm.nih.gov/pubmed/31978148
http://dx.doi.org/10.1371/journal.pone.0228291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980506/
https://www.ncbi.nlm.nih.gov/pubmed/31978148
http://dx.doi.org/10.1371/journal.pone.0228291

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