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Disease-relevant mutations alter amino acid co-evolution networks in the second nucleotide binding domain of CFTR
Cystic Fibrosis (CF) is an inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel. Mutations in CFTR cause impaired chloride ion transport in the epithelial tissues of patients leading to cardiopulmonary decline and pancreatic insufficienc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980524/ https://www.ncbi.nlm.nih.gov/pubmed/31978131 http://dx.doi.org/10.1371/journal.pone.0227668 |