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Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site
The antibiotic resistance crisis is becoming dire, yet in the past several years few potential antibiotics or adjuvants with novel modes of action have been identified. The bacterial mechanosensitive channel of large conductance, MscL, found in the majority of bacterial species, including pathogens,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980572/ https://www.ncbi.nlm.nih.gov/pubmed/31978161 http://dx.doi.org/10.1371/journal.pone.0228153 |