A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib

The combined influence of oncogenic drivers, genomic instability, and/or DNA damage repair deficiencies increases replication stress in cancer. Cells with high replication stress rely on the upregulation of checkpoints like those governed by CHK1 for survival. Previous studies of the CHK1 inhibitor...

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Detalles Bibliográficos
Autores principales: Blosser, Wayne D., Dempsey, Jack A., McNulty, Ann M., Rao, Xi, Ebert, Philip J., Lowery, Caitlin D., Iversen, Philip W., Webster, Yue Wang, Donoho, Gregory P., Gong, Xueqian, Merzoug, Farhana F., Buchanan, Sean, Boehnke, Karsten, Yu, Chunping, You, Xin Tian, Beckmann, Richard P., Wu, Wenjuan, McNeely, Samuel C., Lin, Aimee Bence, Martinez, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980627/
https://www.ncbi.nlm.nih.gov/pubmed/32076484
http://dx.doi.org/10.18632/oncotarget.27400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980627/
https://www.ncbi.nlm.nih.gov/pubmed/32076484
http://dx.doi.org/10.18632/oncotarget.27400

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