The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs

BACKGROUND: Memantine, currently available for the treatment of Alzheimer's disease, is an uncompetitive antagonist of the N-methyl-D-aspartate type of glutamate receptors. Under normal physiologic conditions, these unstimulated receptor ion channels are blocked by magnesium ions, which are dis...

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Detalles Bibliográficos
Autores principales: Bures, Jan, Kvetina, Jaroslav, Radochova, Vera, Tacheci, Ilja, Peterova, Eva, Herman, David, Dolezal, Rafael, Kopacova, Marcela, Rejchrt, Stanislav, Douda, Tomas, Sestak, Vit, Douda, Ladislav, Karasova, Jana Zdarova
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980640/
https://www.ncbi.nlm.nih.gov/pubmed/31978146
http://dx.doi.org/10.1371/journal.pone.0227781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980640/
https://www.ncbi.nlm.nih.gov/pubmed/31978146
http://dx.doi.org/10.1371/journal.pone.0227781

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