Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity

Mitochondrial function in white adipose tissue (WAT) is an important yet understudied aspect in adipocyte biology. Here, we report a role for amyloid precursor protein (APP) in compromising WAT mitochondrial function through a high-fat diet (HFD)-induced, unconventional mis-localization to mitochond...

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Detalles Bibliográficos
Autores principales: An, Yu A., Crewe, Clair, Asterholm, Ingrid Wernstedt, Sun, Kai, Chen, Shiuhwei, Zhang, Fang, Shao, Mengle, Funcke, Jan-Bernd, Zhang, Zhuzhen, Straub, Leon, Klein, Samuel, Kusminski, Christine M., Scherer, Philipp E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980705/
https://www.ncbi.nlm.nih.gov/pubmed/31984308
http://dx.doi.org/10.1038/s42255-019-0149-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980705/
https://www.ncbi.nlm.nih.gov/pubmed/31984308
http://dx.doi.org/10.1038/s42255-019-0149-1

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