Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and - independent cellular responses in Alzheimer’s disease

Glia have been implicated in Alzheimer’s disease (AD) pathogenesis. Variants of the microglia receptor TREM2 increase AD risk and activation of “disease-associated microglia” (DAM) is dependent on TREM2 in mouse models of AD. We surveyed gene expression changes associated with AD pathology and TREM2...

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Detalles Bibliográficos
Autores principales: Zhou, Yingyue, Song, Wilbur M., Andhey, Prabhakar S., Swain, Amanda, Levy, Tyler, Miller, Kelly R., Poliani, Pietro L., Cominelli, Manuela, Grover, Shikha, Gilfillan, Susan, Cella, Marina, Ulland, Tyler K., Zaitsev, Konstantin, Miyashita, Akinori, Ikeuchi, Takeshi, Sainouchi, Makoto, Kakita, Akiyoshi, Bennett, David A., Schneider, Julie A., Nichols, Michael R., Beausoleil, Sean A., Ulrich, Jason, Holtzman, David M., Artyomov, Maxim N., Colonna, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980793/
https://www.ncbi.nlm.nih.gov/pubmed/31932797
http://dx.doi.org/10.1038/s41591-019-0695-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980793/
https://www.ncbi.nlm.nih.gov/pubmed/31932797
http://dx.doi.org/10.1038/s41591-019-0695-9

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