The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

The Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. Bim binds to these proteins via its BH3 domain and to the mitochondrial membrane by a carboxyl-terminal seque...

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Detalles Bibliográficos
Autores principales: Chi, Xiaoke, Nguyen, Dang, Pemberton, James M, Osterlund, Elizabeth J, Liu, Qian, Brahmbhatt, Hetal, Zhang, Zhi, Lin, Jialing, Leber, Brian, Andrews, David W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980855/
https://www.ncbi.nlm.nih.gov/pubmed/31976859
http://dx.doi.org/10.7554/eLife.44525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980855/
https://www.ncbi.nlm.nih.gov/pubmed/31976859
http://dx.doi.org/10.7554/eLife.44525

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