Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway

Ischemia/reperfusion (I/R) injury reduces cell proliferation, triggers inflammation, promotes cell apoptosis and necrosis, which are the leading reasons of morbidity and mortality in patients with cardiac disease. TGR5 is shown to express in hearts, but its functional role in I/R-induced myocardial...

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Detalles Bibliográficos
Autores principales: Li, Junzhi, Cheng, Ruining, Wan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Cell Death & Injury
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981096/
https://www.ncbi.nlm.nih.gov/pubmed/31909787
http://dx.doi.org/10.1042/BSR20193482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981096/
https://www.ncbi.nlm.nih.gov/pubmed/31909787
http://dx.doi.org/10.1042/BSR20193482

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