Nanodisc technology facilitates identification of monoclonal antibodies targeting multi-pass membrane proteins

Multi-pass membrane proteins are important targets of biologic medicines. Given the inherent difficulties in working with membrane proteins, we sought to investigate the utility of membrane scaffold protein nanodiscs as a means of solubilizing membrane proteins to aid antibody discovery. Using a mod...

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Detalles Bibliográficos
Autores principales: Gardill, Bernd, Huang, Jerry, Tu, Lawrence, Van Petegem, Filip, Oxenoid, Kirill, Thomson, Christy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981118/
https://www.ncbi.nlm.nih.gov/pubmed/31980674
http://dx.doi.org/10.1038/s41598-020-58002-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981118/
https://www.ncbi.nlm.nih.gov/pubmed/31980674
http://dx.doi.org/10.1038/s41598-020-58002-w

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