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Nanodisc technology facilitates identification of monoclonal antibodies targeting multi-pass membrane proteins

Multi-pass membrane proteins are important targets of biologic medicines. Given the inherent difficulties in working with membrane proteins, we sought to investigate the utility of membrane scaffold protein nanodiscs as a means of solubilizing membrane proteins to aid antibody discovery. Using a mod...

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Detalles Bibliográficos
Autores principales:	Gardill, Bernd, Huang, Jerry, Tu, Lawrence, Van Petegem, Filip, Oxenoid, Kirill, Thomson, Christy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981118/ https://www.ncbi.nlm.nih.gov/pubmed/31980674 http://dx.doi.org/10.1038/s41598-020-58002-w

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