The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates

Proteins are targeted to the proteasome by the attachment of ubiquitin chains, which are markedly varied in structure. Three proteasome subunits–Rpn10, Rpn13, and Rpn1–can recognize ubiquitin chains. Here we report that proteins with single chains of K48-linked ubiquitin are targeted for degradation...

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Detalles Bibliográficos
Autores principales: Martinez-Fonts, Kirby, Davis, Caroline, Tomita, Takuya, Elsasser, Suzanne, Nager, Andrew R., Shi, Yuan, Finley, Daniel, Matouschek, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981147/
https://www.ncbi.nlm.nih.gov/pubmed/31980598
http://dx.doi.org/10.1038/s41467-019-13906-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981147/
https://www.ncbi.nlm.nih.gov/pubmed/31980598
http://dx.doi.org/10.1038/s41467-019-13906-8

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