Targeting glutamine metabolism slows soft tissue sarcoma growth

Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of rapid cell growth. However, glutamine dependence can be highly variable between in vitro and in vivo settings, based on surrounding microenvironments and complex adaptive responses to glutamine deprivation. So...

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Detalles Bibliográficos
Autores principales: Lee, Pearl, Malik, Dania, Perkons, Nicholas, Huangyang, Peiwei, Khare, Sanika, Rhoades, Seth, Gong, Yao-Yu, Burrows, Michelle, Finan, Jennifer M., Nissim, Itzhak, Gade, Terence P. F., Weljie, Aalim M., Simon, M. Celeste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981153/
https://www.ncbi.nlm.nih.gov/pubmed/31980651
http://dx.doi.org/10.1038/s41467-020-14374-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981153/
https://www.ncbi.nlm.nih.gov/pubmed/31980651
http://dx.doi.org/10.1038/s41467-020-14374-1

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