Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing

Tissue-specific gene expression requires coordinated control of gene-proximal and -distal cis-regulatory elements (CREs), yet functional analysis of gene-distal CREs such as enhancers remains challenging. Here we describe CRISPR/dCas9-based enhancer-targeting epigenetic editing systems, enCRISPRa an...

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Detalles Bibliográficos
Autores principales: Li, Kailong, Liu, Yuxuan, Cao, Hui, Zhang, Yuannyu, Gu, Zhimin, Liu, Xin, Yu, Andy, Kaphle, Pranita, Dickerson, Kathryn E., Ni, Min, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981169/
https://www.ncbi.nlm.nih.gov/pubmed/31980609
http://dx.doi.org/10.1038/s41467-020-14362-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981169/
https://www.ncbi.nlm.nih.gov/pubmed/31980609
http://dx.doi.org/10.1038/s41467-020-14362-5

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