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Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas

The classical development hierarchy of pancreatic cell fate commitments describes that multipotent progenitors (MPs) first bifurcate into tip cells and trunk cells, and then these cells give rise to acinar cells and endocrine/ductal cells separately. However, lineage tracings reveal that pancreatic...

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Detalles Bibliográficos
Autores principales: Wang, Junqiang, Yuan, Ruoshi, Zhu, Xiaomei, Ao, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981170/
https://www.ncbi.nlm.nih.gov/pubmed/31980678
http://dx.doi.org/10.1038/s41598-020-57903-0