Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis

We reported previously that acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1) to its C terminus (CT), independent of its ion-conducting function. Here we show that the N-terminus (NT) of ASIC1a interacts with its CT...

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Detalles Bibliográficos
Autores principales: Wang, Jing-Jing, Liu, Fan, Yang, Fan, Wang, Yi-Zhi, Qi, Xin, Li, Ying, Hu, Qin, Zhu, Michael X., Xu, Tian-Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981194/
https://www.ncbi.nlm.nih.gov/pubmed/31980622
http://dx.doi.org/10.1038/s41467-019-13873-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981194/
https://www.ncbi.nlm.nih.gov/pubmed/31980622
http://dx.doi.org/10.1038/s41467-019-13873-0

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