PTH induces bone loss via microbial-dependent expansion of intestinal TNF(+) T cells and Th17 cells

Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing taxa segmented filamentous bacteria (SFB). SFB(+) mi...

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Detalles Bibliográficos
Autores principales: Yu, Mingcan, Malik Tyagi, Abdul, Li, Jau-Yi, Adams, Jonathan, Denning, Timothy L., Weitzmann, M. Neale, Jones, Rheinallt M., Pacifici, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981196/
https://www.ncbi.nlm.nih.gov/pubmed/31980603
http://dx.doi.org/10.1038/s41467-019-14148-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981196/
https://www.ncbi.nlm.nih.gov/pubmed/31980603
http://dx.doi.org/10.1038/s41467-019-14148-4

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