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DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions

Regulation of transcription occurs in a cell type specific manner orchestrated by epigenetic mechanisms including DNA methylation. Methylation changes may also play a key role in lineage specification during stem cell differentiation. To further our understanding of epigenetic regulation in chondroc...

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Detalles Bibliográficos
Autores principales: Barter, Matt J., Bui, Catherine, Cheung, Kathleen, Falk, Julia, Gómez, Rodolfo, Skelton, Andrew J., Elliott, Hannah R., Reynard, Louise N., Young, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981252/
https://www.ncbi.nlm.nih.gov/pubmed/31980739
http://dx.doi.org/10.1038/s41598-020-58093-5