YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

The timing and characteristics of neuronal death in Alzheimer’s disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS), and reveal an increase of neuronal necrosis during...

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Detalles Bibliográficos
Autores principales: Tanaka, Hikari, Homma, Hidenori, Fujita, Kyota, Kondo, Kanoh, Yamada, Shingo, Jin, Xiaocen, Waragai, Masaaki, Ohtomo, Gaku, Iwata, Atsushi, Tagawa, Kazuhiko, Atsuta, Naoki, Katsuno, Masahisa, Tomita, Naoki, Furukawa, Katsutoshi, Saito, Yuko, Saito, Takashi, Ichise, Ayaka, Shibata, Shinsuke, Arai, Hiroyuki, Saido, Takaomi, Sudol, Marius, Muramatsu, Shin-ichi, Okano, Hideyuki, Mufson, Elliott J., Sobue, Gen, Murayama, Shigeo, Okazawa, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981281/
https://www.ncbi.nlm.nih.gov/pubmed/31980612
http://dx.doi.org/10.1038/s41467-020-14353-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981281/
https://www.ncbi.nlm.nih.gov/pubmed/31980612
http://dx.doi.org/10.1038/s41467-020-14353-6

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