Theoretical analyses and experimental validation of the effects caused by the fluorinated substituent modification of DNA

Halogen-modified nucleic acid molecules, such as trifluorothymidine (FTD) and 5-fluorouracil, are widely used in medical science and clinical site. These compounds have a very similar nucleobase structure. It is reported that both of these compounds could be incorporated into DNA. The incorporation...

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Detalles Bibliográficos
Autores principales: Koseki, Jun, Konno, Masamitsu, Asai, Ayumu, Horie, Naohiro, Tsunekuni, Kenta, Kawamoto, Koichi, Obika, Satoshi, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981298/
https://www.ncbi.nlm.nih.gov/pubmed/31980685
http://dx.doi.org/10.1038/s41598-020-57899-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981298/
https://www.ncbi.nlm.nih.gov/pubmed/31980685
http://dx.doi.org/10.1038/s41598-020-57899-7

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