SP-8356, a Novel Inhibitor of CD147-Cyclophilin A Interactions, Reduces Plaque Progression and Stabilizes Vulnerable Plaques in apoE-Deficient Mice

Interactions between CD147 and cyclophilin A (CypA) promote plaque rupture that causes atherosclerosis-related cardiovascular events, such as myocardial infarction and stroke. Here, we investigated whether SP-8356 ((1S,5R)-4-(3,4-dihydroxy-5-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one),...

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Detalles Bibliográficos
Autores principales: Pahk, Kisoo, Joung, Chanmin, Song, Hwa Young, Kim, Sungeun, Kim, Won-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981359/
https://www.ncbi.nlm.nih.gov/pubmed/31877775
http://dx.doi.org/10.3390/ijms21010095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981359/
https://www.ncbi.nlm.nih.gov/pubmed/31877775
http://dx.doi.org/10.3390/ijms21010095

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