Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

We designed, synthesized, and evaluated novel 2,6,9-trisubstituted purine derivatives for their prospective role as antitumor compounds. Using simple and efficient methodologies, 31 compounds were obtained. We tested these compounds in vitro to draw conclusions about their cell toxicity on seven can...

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Detalles Bibliográficos
Autores principales: O. Salas, Cristian, Zarate, Ana Maria, Kryštof, Vladimir, Mella, Jaime, Faundez, Mario, Brea, Jose, Loza, María Isabel, Brito, Ivan, Hendrychová, Denisa, Jorda, Radek, Cabrera, Alan R., Tapia, Ricardo A., Espinosa-Bustos, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981454/
https://www.ncbi.nlm.nih.gov/pubmed/31881717
http://dx.doi.org/10.3390/ijms21010161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981454/
https://www.ncbi.nlm.nih.gov/pubmed/31881717
http://dx.doi.org/10.3390/ijms21010161

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