Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

The anti-tumor activity of diosgenin, a new steroidal constituent present in fenugreek, on two human breast cancer cell lines, MCF-7 and Hs578T, was studied. Diosgenin treatment resulted in cell growth inhibition, cell cycle arrest, and apoptosis in concentration- and time-dependent manners in both...

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Detalles Bibliográficos
Autores principales: Liao, Wen-Ling, Lin, Jing-Yi, Shieh, Jia-Ching, Yeh, Hsiao-Fong, Hsieh, Yi-Hsien, Cheng, Yu-Chun, Lee, Huei-Jane, Shen, Chen-Yang, Cheng, Chun-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981609/
https://www.ncbi.nlm.nih.gov/pubmed/31881805
http://dx.doi.org/10.3390/ijms21010172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981609/
https://www.ncbi.nlm.nih.gov/pubmed/31881805
http://dx.doi.org/10.3390/ijms21010172

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