Screening and Identification of Novel cGAS Homologues Using a Combination of in Vitro and In Vivo Protein Synthesis

The cyclic GMP-AMP synthase (cGAS) catalyzes the synthesis of the multifunctional second messenger, cGAMP, in metazoans. Although numerous cGAS homologues are predicted in protein databases, the catalytic activity towards cGAMP synthesis has been proven for only four of them. Therefore, we selected...

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Detalles Bibliográficos
Autores principales: Rolf, Jascha, Siedentop, Regine, Lütz, Stephan, Rosenthal, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981698/
https://www.ncbi.nlm.nih.gov/pubmed/31877895
http://dx.doi.org/10.3390/ijms21010105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981698/
https://www.ncbi.nlm.nih.gov/pubmed/31877895
http://dx.doi.org/10.3390/ijms21010105

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