Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations

The selective PPARα modulator (SPPARMα) is expected to medicate dyslipidemia with minimizing adverse effects. Recently, pemafibrate was screened from the ligand library as an SPPARMα bearing strong potency. Several clinical pieces of evidence have proved the usefulness of pemafibrate as a medication...

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Detalles Bibliográficos
Autores principales: Kawasaki, Mayu, Kambe, Akira, Yamamoto, Yuta, Arulmozhiraja, Sundaram, Ito, Sohei, Nakagawa, Yoshimi, Tokiwa, Hiroaki, Nakano, Shogo, Shimano, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981837/
https://www.ncbi.nlm.nih.gov/pubmed/31935812
http://dx.doi.org/10.3390/ijms21010361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981837/
https://www.ncbi.nlm.nih.gov/pubmed/31935812
http://dx.doi.org/10.3390/ijms21010361

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