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Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma

Internal ribosome entry site (IRES)-mediated protein synthesis has been demonstrated to play an important role in resistance to mechanistic target of rapamycin (mTOR) targeted therapies. Previously, we have demonstrated that the IRES trans-acting factor (ITAF), hnRNP A1 is required to promote IRES a...

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Detalles Bibliográficos
Autores principales: Benavides-Serrato, Angelica, Saunders, Jacquelyn T., Holmes, Brent, Nishimura, Robert N., Lichtenstein, Alan, Gera, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981868/
https://www.ncbi.nlm.nih.gov/pubmed/31948038
http://dx.doi.org/10.3390/ijms21010344